• July 25, 2024

10 Things You Need to Know About DNA & RNA Vaccines for Livestock

 10 Things You Need to Know About DNA & RNA Vaccines for Livestock


By The Sharp Edge

1. What are the different terms used for DNA or RNA-based veterinary biologics?

Not all genetic technologies used in veterinary medicine fall under the categories of “mRNA vaccines” or “mRNA gene therapies.” There are other terms to look out for when it comes to genetic technologies for veterinary medicine. These terms also include:

“RNA Particle Technology”“RNA Particle Platform”“DNA Vaccine”“DNA Immunostimulant”“Prescription Platform Product”

2. How do DNA or RNA-based veterinary biologics work?

With SEQUIVITY’s RNA Particle Technology, a “gene of interest provides instructions” to the immune cells which “translate the sequence into proteins” that “act as antigens.” This triggers an immune response.

As for AgriLab’s ExactVac DNA technology, “the vaccine is produced by splicing a gene for a specific antigen” into “a bacterial plasmid” which “is then multiplied, purified and administered” for “delivery into target cells, where antigens produced by the plasmid elicit an immune response.”

Bayer’s Zelnate DNA immunostimulant is “made up of a special type of immunostimulatory DNA surrounded by a lipid carrier or liposome” which is then “engulfed by the animal’s immune cell” where the “liposome breaks down exposing the DNA” and the “pathogen-associated molecular pattern” of the DNA “attaches to the immune cell’s toll-like receptors triggering activation of the immune cell.”

3. Which agency approves veterinary biologics?

The USDA’s Animal and Plant Health Inspection ServiceRead More

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